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  • Evidence is increasing that every addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This area of the problem regulates reward responses in acquiring food and sex, plus nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to lose weight naturally can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you ought to err on the side of caution and let the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on their medications.

    Researchers discovered that participants investing in this drug for a year, lost weight within four weeks and have kept the extra weight off through the entire 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which can be made up of many active ingredient, that might make them far better and safer.

    Combo-pilling may be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular may be the fact that at the time of right now there aren't long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA.

    Seizures can be a side effect with Contrave and must not be taken in people with seizure disorders. The drug may also raise blood pressure level and pulse rate, and must not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not be used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.

    Most of the combinations which can be used to enhance fat loss involve an amphetamine as well as an antidepressant. Phentermine and Prozac are a popular combination that have been around for some time, although it has been around stuffed to truly combine the two and try to get FDA approval to showcase it as a weight-loss pill. Right there should raise some warning flag if the greedy pharmaceutical companies do not want to be involved in combining medications and selling them something should be wrong using the combination. In fairness there is certainly one weight loss combination pill that's in front of the FDA now Contrave?which couples naltrexone, utilized to treat alcohol and substance abuse, using the antidepressant bupropion (Wellbutrin, Zyban) it's been given the proceed to move forward by an FDA advisory committee, but by yet has not been approved.