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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, so long as they also have problems with weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and also have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes established that patients had a normal weight loss of 4.1% as opposed to participants who have been given placebos) after a 12- month period, while a separate study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to lose weight naturally can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you need to err to the side of caution and permit the FDA do its job and demand some investigation be done so the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on their medications.

    Researchers found that participants using this drug to get a year, lost weight within one month and have kept the load off during the entire 56 weeks with the study. Contrave can be a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, that might make them more effective and safer.

    Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular will be the fact that as of right now there are not any long term prescription weight loss supplements that have been authorized by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

    Seizures can be a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug may also raise blood pressure levels and heartbeat, and mustn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure and pulse rate and must 't be used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients to the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

    "This will be the first drug I'm mindful of that targets both appetite and reward centres inside the brain," he explained.