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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) greater than 27, provided they also have problems with weight-related health issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle including a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercise. Results from a medical trial that enrolled patients without diabetes indicated that patients had an average weight loss of 4.1% instead of participants have been given placebos) within a 12- month period, while another study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at 12 months.

    Using two separate drugs to shed weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it you need to err assisting caution and allow FDA do its job and demand some research be done in order that the public understands the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on the medications.

    Researchers discovered that participants using this drug for any year, dropped a few pounds within 4 weeks and have kept the weight off during the entire 56 weeks in the study. Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which can be made up of more than one active ingredient, that might make them far better and safer.

    Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular will be the fact that by right now there aren't any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA.

    Seizures really are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug could also raise blood pressure levels and pulse rate, and must not be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure level and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, in addition to by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    "There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.