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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, so long as they also suffer from weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had the average weight loss of four.1% instead of participants who have been given placebos) throughout a 12- month period, while a different study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to shed pounds can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err along the side of caution and let the FDA do its job and demand some study be done so that the public understands the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies come in business to generate money and that they would say almost anything to keep people on their own medications.

    Researchers found out that participants using this drug for a year, dropped excess weight within one month and have kept the extra weight off throughout the 56 weeks from the study. Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them more efficient and safer.

    Combo-pilling is the newest fad or in addition to this the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that as of right now there aren't long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise blood pressure level and heart rate, and really should not be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure level and heartrate and must not be used in patients with uncontrolled high blood pressure, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients to the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

    From a psychiatric perspective, evidence points too the ordinary neural mechanism for goal-directed behavior may be hijacked through the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object generates a stimulus as well as the person engages in a "goal-directed behavioral response" that produces a "natural high"(Bostwick & Bucci, 2008).